Bref(1)

NAME
Bref - Tool for compressing diploid reference VCF files for the Beagle program.

SYNOPSIS
java -jar /usr/share/beagle/bref.jar [vcf]
or
java -jar /usr/share/beagle/bref.jar [bref]

DESCRIPTION
Bref is a tool for compressing diploid reference VCF files.
Beagle performs genotype calling, genotype phasing, imputation of ungenotyped markers, and identity-by-descent segment detection. Genotypic imputation works on phased haplotypes using a Li and Stephens haplotype frequency model. Beagle also implements the Refined IBD algorithm for detecting homozygosity-by-descent (HBD) and identity-by-descent (IBD) segments.

OPTIONS

vcf=filename
    Creates a .bref file.
    Specifies a VCF file with phase, non-missing genotype data. If the VCF file is a text file, its filename should end in ".vcf". If the VCF file is GZIP-compressed, its filename should end in ".vcf.gz".

bref=filename
    Prints a .vcf file to standard out.
    Specifies a binary reference file. The filename should end in ".bref".

SEE ALSO
https://faculty.washington.edu/browning/beagle/beagle.html

AUTHOR
Beagle and Bref were written by Brian L. Browning.

This manual page was written by Dylan Aïssi <bob.dybian@gmail.com>, for the Debian project (but may be used by others).